Improved oxygenation after muscle relaxation in adult respiratory distress syndrome

Arterial blood oxygenation improved repeatedly after sedation and paralysis in a 27-year-old woman requiring mechanical ventilation for the adult respiratory distress syndrome. Oxygen consumption and cardiac output decreased proportionately after paralysis so that the partial pressure of oxygen in m...

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Bibliographic Details
Published inArchives of internal medicine (1960) Vol. 145; no. 9; p. 1718
Main Authors Coggeshall, J W, Marini, J J, Newman, J H
Format Journal Article
LanguageEnglish
Published United States 01.09.1985
Subjects
Adult
Female
Humans
Muscle Relaxants, Central - therapeutic use
Oxygen - blood
Pancuronium - therapeutic use
Pulmonary Wedge Pressure
Respiration, Artificial
Respiratory Distress Syndrome, Adult - blood
Respiratory Distress Syndrome, Adult - therapy
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Summary:Arterial blood oxygenation improved repeatedly after sedation and paralysis in a 27-year-old woman requiring mechanical ventilation for the adult respiratory distress syndrome. Oxygen consumption and cardiac output decreased proportionately after paralysis so that the partial pressure of oxygen in mixed venous blood remained unchanged. Paralysis eliminated inspiratory distortion of the airway pressure waveform and prevented forceful use of expiratory musculature. A flow-related reduction of venous admixture or recruitment of lung volume may best explain the beneficial effect of muscle relaxation on arterial saturation.
ISSN:0003-9926
DOI:10.1001/archinte.1985.00360090194030