Energetic Material Synthesis: Scale-up Using a Novel Modular Microflow Reactor Setup

The advantages of microflow reactors have proven to be manifold, e.g., the excellent cooling ability, which allows performing exothermic reactions like nitrations safely. A critical point remains the transition from gram scale to industrial production. On an industrial scale, they are often designed...

Full description

Saved in:
Bibliographic Details
Published inOrganic process research & development Vol. 28; no. 5; pp. 1458 - 1463
Main Authors Karaghiosoff, Konstantin, Klapötke, Thomas M., Völkl, Maurus B. R.
Format Journal Article
LanguageEnglish
Published American Chemical Society 17.05.2024
Subjects
continuous flow
flow reactor
nitroguanidine
high corrosion
upscaling
silica coating
Energetic material
Online AccessGet full text

Cover

More Information
Summary:The advantages of microflow reactors have proven to be manifold, e.g., the excellent cooling ability, which allows performing exothermic reactions like nitrations safely. A critical point remains the transition from gram scale to industrial production. On an industrial scale, they are often designed for specific syntheses and are therefore less useful for a conventional research laboratory. A reactor setup was successfully developed mitigating these shortcomings and allowing the use of highly corrosive materials, like fuming inorganic acids (e.g., nitric, sulfuric acid), bases (e.g., bleach solutions), and chlorinated solvents. As a proof of functionality, the synthesis of nitroguanidine has been performed on a lab scale and was significantly improved over reported batch syntheses in terms of safety and production rate. A scale-up to industrial scale has hence become feasible.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.2c00398