Histamine2 antagonists in allergic rhinitis. Possible role in the control of cellular immune reaction

We studied effects of monoclonal antibodies on lymphocyte subpopulations in patients with allergic rhinitis treated with histamine2 antagonists. The OKT4/OKT8 ratio after treatment showed a statistically significant decrease compared with initial values, the expression of a relative increase in the...

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Bibliographic Details
Published inArchives of otolaryngology--head & neck surgery Vol. 112; no. 4; p. 432
Main Authors Testa, B, Mesolella, C, Costa, F, Catalanotti, P G, Benedetto, N, Mattera, S
Format Journal Article
LanguageEnglish
Published United States 01.04.1986
Subjects
Adolescent
Adult
Antibodies, Monoclonal
Child
Female
Histamine H2 Antagonists - pharmacology
Humans
Immunoglobulin E - analysis
Male
Rhinitis - drug therapy
Rhinitis - immunology
T-Lymphocytes, Regulatory - drug effects
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Summary:We studied effects of monoclonal antibodies on lymphocyte subpopulations in patients with allergic rhinitis treated with histamine2 antagonists. The OKT4/OKT8 ratio after treatment showed a statistically significant decrease compared with initial values, the expression of a relative increase in the OKT8 subpopulation containing the suppressor fraction. In control patients no significant variations were observed. These results confirm our hypothesis that histamine2 antagonists act in allergic rhinitis by modulating the activity of T-suppressor lymphocytes reduced in atopic patients.
ISSN:0886-4470
DOI:10.1001/archotol.1986.03780040072014