Gd(III)-Grafted Detonation Nanodiamonds for MRI Contrast Enhancement

We report on the first 1H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd­(III) ions. In contrast to Gd­(III)–ND conjugates implemented via organic species, Gd­(III) ions were directly grafted to the surface of DND partic...

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Published inJournal of physical chemistry. C Vol. 123; no. 4; pp. 2627 - 2631
Main Authors Panich, A. M, Salti, M, Goren, S. D, Yudina, E. B, Aleksenskii, A. E, Vul’, A. Ya, Shames, A. I
Format Journal Article
LanguageEnglish
Published American Chemical Society 31.01.2019
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Summary:We report on the first 1H NMR relaxation and magnetic resonance imaging (MRI) study of aqueous suspensions of detonation nanodiamond (DND) grafted by Gd­(III) ions. In contrast to Gd­(III)–ND conjugates implemented via organic species, Gd­(III) ions were directly grafted to the surface of DND particles. Such Gd­(III)-grafted DND particles significantly shorten spin–lattice (T 1) and spin–spin (T 2) relaxation times of water protons providing relaxivities of r 1 = 33.4 and r 2 = 332 mM–1 s–1, which considerably exceed most of those reported in the literature. It makes the Gd­(III)-grafted DND complexes attractive for use as novel MRI contrast agents.
ISSN:1932-7447
1932-7455
DOI:10.1021/acs.jpcc.8b11655