Effective Method To Remove Metal Elements from Pharmaceutical Intermediates with Polychelated Resin Scavenger

A catalytic reaction is an important methodology for the production of pharmaceuticals from the viewpoint of green and sustainable chemistry. Since elemental impurity levels should be controlled within acceptable limits in API, the development of removal of element is also important as well. The tec...

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Published inOrganic process research & development Vol. 19; no. 8; pp. 1054 - 1061
Main Authors Miyamoto, Hidetoshi, Sakumoto, Chihiro, Takekoshi, Eriko, Maeda, Yukiko, Hiramoto, Narumi, Itoh, Takahiro, Kato, Yoshiaki
Format Journal Article
LanguageEnglish
Published American Chemical Society 21.08.2015
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Summary:A catalytic reaction is an important methodology for the production of pharmaceuticals from the viewpoint of green and sustainable chemistry. Since elemental impurity levels should be controlled within acceptable limits in API, the development of removal of element is also important as well. The technology for removal of elements was developed using cost-effective polychelated resin scavenger. The precious elements were removed efficiently by passing through the packed cartridge filled with appropriate scavenger. The feasibility of the scavenger was evaluated, and the application for actual manufacturing process is described. In contrast to another type of immobilized scavengers, polychelated resin scavenger provides an inexpensive method to scavenge several elements.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.5b00161