General Principles and Strategies for Salting-Out Informed by the Hofmeister Series

Overarching principles for salting-out extraction are long-established but poorly disseminated. We highlight the opportunity for more widespread application of this technique using the Hofmeister series as a foundational basis for choosing the right salt. The power of this approach is exemplified by...

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Published inOrganic process research & development Vol. 21; no. 9; pp. 1355 - 1370
Main Authors Hyde, Alan M, Zultanski, Susan L, Waldman, Jacob H, Zhong, Yong-Li, Shevlin, Michael, Peng, Feng
Format Journal Article
LanguageEnglish
Published American Chemical Society 15.09.2017
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Summary:Overarching principles for salting-out extraction are long-established but poorly disseminated. We highlight the opportunity for more widespread application of this technique using the Hofmeister series as a foundational basis for choosing the right salt. The power of this approach is exemplified by the aqueous workup of a highly water-soluble nucleoside in which the use of sodium sulfate allowed for high recoveries without relying on back extraction.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.7b00197