Host–Guest Interaction Studies of Isoproterenol Hydrochloride with Β‑Cyclodextrin in an Aqueous Medium Probed by Volumetric, Acoustic, and Spectroscopic Approach
In this work, we attempted to analyze thermochemical properties along with a spectroscopy approach to better understand the molecular interactions between β-cyclodextrin (β-CD) and the pharmaceutical compound isoproterenol hydrochloride (IPH) in an aqueous solution at a range of temperatures startin...
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Published in | Journal of chemical and engineering data Vol. 68; no. 12; pp. 3099 - 3109 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
American Chemical Society
14.12.2023
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Subjects | |
Online Access | Get full text |
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Summary: | In this work, we attempted to analyze thermochemical properties along with a spectroscopy approach to better understand the molecular interactions between β-cyclodextrin (β-CD) and the pharmaceutical compound isoproterenol hydrochloride (IPH) in an aqueous solution at a range of temperatures starting from 293.15 to 313.15 K at an atmospheric pressure P = 0.1 MPa. The volumetric and rheological properties of IPH, such as apparent molar volume and apparent molar isentropic compressibility, with their corresponding limiting parameters in the variable compositions of β-cyclodextrin (0.001, 0.005, and 0.010 mol·kg–1), were enumerated at different temperatures using the measured density and speed of sound measurements. Transfer parameters reveal dominant hydrophilic–hydrophilic interactions in a ternary system. In addition to this, the sign of ( ∂ E φ o ∂ T ) P points toward the structure-breaking characteristics of IPH in the binary and ternary solutions. A proton NMR titration experiment illustrated that IPH was incorporated into a hydrophobic pocket of β-CD with a 1:1 stoichiometry which was confirmed by Scott’s plot, and a binding energy of 22.5 M–1 was found for the IPH−β-CD complex. |
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ISSN: | 0021-9568 1520-5134 |
DOI: | 10.1021/acs.jced.3c00355 |