Angiolymphoid hyperplasia with eosinophilia of the orbit and ocular adnexa: report of 5 cases

• Published in: JAMA ophthalmology Vol. 132; no. 5; p. 633
• Main Authors: Azari, Amir A, Kanavi, Mozhgan R, Lucarelli, Mark, Lee, Vivian, Lundin, Ashley M, Potter, Heather D, Albert, Daniel M
• Format: Journal Article
• Language: English
• Published: United States 01.05.2014
• Subjects: Adult; Aged, 80 and over; Angiolymphoid Hyperplasia with Eosinophilia - diagnosis; Biopsy; Child; Diagnosis, Differential; Eyelid Diseases - diagnosis; Female; Humans; Male; Middle Aged; Orbit - diagnostic imaging; Orbit - pathology; Orbital Diseases - diagnosis; Tomography, X-Ray Computed
• ISSN: 2168-6173
• DOI: 10.1001/jamaophthalmol.2013.8243

To report the clinical and histopathologic findings of ocular adnexal angiolymphoid hyperplasia with eosinophilia, an unusual but often misdiagnosed benign disorder. The ophthalmologic findings of angiolymphoid hyperplasia with eosinophilia with ocular adnexal involvement are variable and include eyelid swelling, ptosis, proptosis, and loss of vision. Imaging studies typically reveal a well-circumscribed mass in the orbit. The condition may resemble other diseases that involve the orbit and ocular adnexal tissue, such as lymphoma, hemangioma, sarcoidosis, and dermoid cyst. Histopathologic analysis reveals marked vascular proliferation with an accompanying inflammation composed of numerous eosinophils, lymphocytes, and plasma cells. Angiolymphoid hyperplasia with eosinophilia is a rare disease that can affect the ocular adnexal tissue. The clinical presentation is often nonspecific; therefore, histopathologic studies are essential for diagnosis and subsequent management of this benign condition.