Highly Effective DNA Photocleavage by Novel “Rigid” Ru(bpy)3-4-nitro- and -4-amino-1,8-naphthalimide Conjugates

• Published in: Inorganic chemistry Vol. 47; no. 2; pp. 401 - 403
• Main Authors: Ryan, Gary J, Quinn, Susan, Gunnlaugsson, Thorfinnur
• Format: Journal Article
• Language: English
• Published: American Chemical Society 21.01.2008
• ISSN: 0020-1669; 1520-510X
• DOI: 10.1021/ic700967y

The synthesis of the two novel 1,8-naphthalimideruthenium conjugates Ru-Nap-NO 2 and Ru-Nap-NH 2 and their photophysical evaluation upon interaction with DNA is reported. Significant changes were seen in both the absorption and emission spectra upon interaction of both conjugates with DNA, from which large binding constants were determined. Moreover, highly efficient DNA cleavage was observed upon irradiation for 5 min, during which supercoiled DNA was converted to nicked and linear DNA by Ru-Nap-NH 2 .