Olanzapine Salts and Diversity in Molecular Packing

• Published in: Crystal growth & design Vol. 16; no. 2; pp. 1047 - 1055
• Main Authors: Sarmah, Kashyap Kumar, Sarma, Ayushree, Roy, Karabi, Rao, Dharmaraj R, Thakuria, Ranjit
• Format: Journal Article
• Language: English
• Published: American Chemical Society 03.02.2016
• ISSN: 1528-7483; 1528-7505
• DOI: 10.1021/acs.cgd.5b01605

Olanzapine (OLN), an antipsychotic drug of biopharmaceutical classification system (BCS) class II, has been studied extensively in the literature. A large number of solvates, stoichiometric hydrates, salts, cocrystals, and polymorphs were reported, categorized into four different packing types A, B, C, and D. Among them most of the solvated structures belong to type C packing, whereas other multicomponent structures show diversity in packing and are categorized into A, B, and D classes. Some of the reported salts (disalts) even show new packing types lacking the most common OLN dimer motif. Compared to other multicomponent systems, only a few OLN salts were reported. A scope is there to study the possible crystalline arrangement for this unexplored category with various salt formers such as glycolic acid (Gly), 4-hydroxybenzoic acid (4HBA), 2,4-dihydroxybenzoic acid (24DHBA), 2,5-dihydroxybenzoic acid (25DHBA), 2,6-dihydroxybenzoic acid (26DHBA), and p-toluenesulfonic acid (pTSA) containing available hydrogen bonding sites with positional variation. The highlight of this work is the DHBA salts that show a new packing arrangement (type E) whereas Gly, 4HBA, and pTSA salts belong to the reported categories.