片腎摘出糖尿病誘発マウスに於ける腎糸球体病変の検索
あらかじめ片腎を摘出したマウスにストレプトゾトシン(SZ)を投与(50mg/kg/day×5days)することにより糖尿病を誘発した. SZ投与終了後4週おきに剖検を行い, 12週後(12WAI)まで検索を行った. 片腎摘出糖尿病マウスでは4WAIからメサンジウム領域の拡張が認められ, 12WAIでは分節状の糸球体硬化症にまで発展した. 電子顕微鏡による観察では顕著なメサンジウム領域の拡張に加え, 分節状の糸球体基底膜の肥厚および上皮細胞の足突起の癒合, 毛細血管内皮細胞の微絨毛の増加などが認められた. 一方, 片腎摘出を行っていない糖尿病誘発マウスの糸球体では12WAIの時点でも弱から中程度...
Saved in:
| Published in | Journal of Veterinary Medical Science Vol. 54; no. 6; pp. 1085 - 1090 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
公益社団法人 日本獣医学会
1992
|
| Online Access | Get full text |
| ISSN | 0916-7250 1347-7439 |
| DOI | 10.1292/jvms.54.1085 |
Cover
| Abstract | あらかじめ片腎を摘出したマウスにストレプトゾトシン(SZ)を投与(50mg/kg/day×5days)することにより糖尿病を誘発した. SZ投与終了後4週おきに剖検を行い, 12週後(12WAI)まで検索を行った. 片腎摘出糖尿病マウスでは4WAIからメサンジウム領域の拡張が認められ, 12WAIでは分節状の糸球体硬化症にまで発展した. 電子顕微鏡による観察では顕著なメサンジウム領域の拡張に加え, 分節状の糸球体基底膜の肥厚および上皮細胞の足突起の癒合, 毛細血管内皮細胞の微絨毛の増加などが認められた. 一方, 片腎摘出を行っていない糖尿病誘発マウスの糸球体では12WAIの時点でも弱から中程度のメサンジウム領域の拡張が認められたのみであった. また興味深いことに, 糖尿病を誘発していないマウスにおいてはボウマン嚢壁は立方上皮または低円柱上皮(male-type epithelium)によって覆われていたのに対し, 糖尿病誘発マウスにおいては扁平な上皮によって覆われていた. |
|---|---|
| AbstractList | あらかじめ片腎を摘出したマウスにストレプトゾトシン(SZ)を投与(50mg/kg/day×5days)することにより糖尿病を誘発した. SZ投与終了後4週おきに剖検を行い, 12週後(12WAI)まで検索を行った. 片腎摘出糖尿病マウスでは4WAIからメサンジウム領域の拡張が認められ, 12WAIでは分節状の糸球体硬化症にまで発展した. 電子顕微鏡による観察では顕著なメサンジウム領域の拡張に加え, 分節状の糸球体基底膜の肥厚および上皮細胞の足突起の癒合, 毛細血管内皮細胞の微絨毛の増加などが認められた. 一方, 片腎摘出を行っていない糖尿病誘発マウスの糸球体では12WAIの時点でも弱から中程度のメサンジウム領域の拡張が認められたのみであった. また興味深いことに, 糖尿病を誘発していないマウスにおいてはボウマン嚢壁は立方上皮または低円柱上皮(male-type epithelium)によって覆われていたのに対し, 糖尿病誘発マウスにおいては扁平な上皮によって覆われていた. |
| Author | 土居, 千代 久米, 英介 長島, 吉和 板垣, 慎一 土井, 邦雄 |
| Author_xml | – sequence: 1 fullname: 板垣, 慎一 – sequence: 1 fullname: 久米, 英介 – sequence: 1 fullname: 長島, 吉和 – sequence: 1 fullname: 土居, 千代 – sequence: 1 fullname: 土井, 邦雄 |
| BackLink | https://agriknowledge.affrc.go.jp/RN/2010480405$$DView record in AgriKnowledge |
| BookMark | eNo9kE1LAlEYhS9RkFq7_sbY_Zp75y5D7IOENrW-3BlnbCZ1ZEaKlioiEkQSmEG0CGlREIEtSop-zKTjz2jEaHPexXnOy-GkwXLVr9oAbCCYRVjgTe-0EmZ1mkXQ0JdAChHKNU6JWAYpKBDTONbhKkiHoQchRpSJFNiPu51Z-3LaG0w643jUn7x-xzft2dMgvh1Hrfuo-Rg1P6LG87T_GTV6UfMigePRe3zV-vm6TsjJsBs1XqbDu_jtYQ2sOKoc2ut_NwOOtvOHuV2tcLCzl9sqaApzDjWHQMGRSSwTI8ZsiC2uF5MyDlVKUW5RppsGRAaiJsWC27CoE0aZw7hhEC4UyQC--KscJ3DrUpUC96Tqn5XtYsmWvnLl3LBkyZdeTUIkIaScIMSSZH6R9MK6Stha4FZUcC5VUHetsi3nAyIhkNSpZAuZb_nvW8cqkJ4iv_EYiDc |
| ContentType | Journal Article |
| Copyright | 社団法人 日本獣医学会 |
| Copyright_xml | – notice: 社団法人 日本獣医学会 |
| DBID | ABELO |
| DOI | 10.1292/jvms.54.1085 |
| DatabaseName | AgriKnowledge (アグリナレッジ) JASI |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Veterinary Medicine |
| EISSN | 1347-7439 |
| EndPage | 1090 |
| ExternalDocumentID | oai_affrc_go_jp_01_00473116 article_jvms1991_54_6_54_6_1085_article_char_ja |
| GroupedDBID | 29L 2WC 53G 5GY ACGFO ACIWK ACPRK ADBBV AENEX AFRAH AI. ALMA_UNASSIGNED_HOLDINGS BAWUL CS3 DIK DU5 E3Z EBS EJD JSF JSH KQ8 OK1 OVT P2P PGMZT RJT RNS RZJ TKC TR2 VH1 ABELO ADRAZ AOIJS B.T ECGQY EYRJQ HYE M48 N5S RPM XSB |
| ID | FETCH-LOGICAL-a2770-f30971b3cb2166e02c75d469f4aaa47c465b801814b4297e0d53646f6788379a3 |
| ISSN | 0916-7250 |
| IngestDate | Fri Aug 15 12:22:19 EDT 2025 Wed Sep 03 06:24:47 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-a2770-f30971b3cb2166e02c75d469f4aaa47c465b801814b4297e0d53646f6788379a3 |
| Notes | 480405 ZZ00004754 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jvms1991/54/6/54_6_1085/_article/-char/ja |
| PageCount | 6 |
| ParticipantIDs | affrit_agriknowledge_oai_affrc_go_jp_01_00473116 jstage_primary_article_jvms1991_54_6_54_6_1085_article_char_ja |
| PublicationCentury | 1900 |
| PublicationDate | 19920000 |
| PublicationDateYYYYMMDD | 1992-01-01 |
| PublicationDate_xml | – year: 1992 text: 19920000 |
| PublicationDecade | 1990 |
| PublicationTitle | Journal of Veterinary Medical Science |
| PublicationTitleAlternate | J. Vet. Med. Sci. |
| PublicationYear | 1992 |
| Publisher | 公益社団法人 日本獣医学会 |
| Publisher_xml | – name: 公益社団法人 日本獣医学会 |
| References | Iwase, M., Kikuchi, M., Nunoi, K., Wakisaka, M., Maki, Y., Sadoshima, S., and Fujishima M. 1986. A new model of type 2 (non-insulin-dependent) diabetes induced by neonatal streptozotocin treatment. Diabetrogia 29: 808-811. Like, A. A., Appel, M. C., Williams, R. M., and Possini, A. A. 1978. Streptozotocin-induced pancreatic insulitis in mice. Morphologic and physiologic studies. Lab. Invest. 38: 470-486. Jakobson, J., Sidenius, P., Gunderson, H. J. G., and Osterby, R. 1987. Quantitive changes of cerebral neocortical structure in insulin-treated long-term streptozotocin-induced diabetes in rats. Diabetes 36: 597-601. Steffes, M. W. and Mauer, S. M. 1984. Diabetic Glomerulopathy in man and experimental models. Int. Review of Exp. Pathol. 26: 147-175. Liebert, A. G. 1986. Unique feature of anatomy, histology, and ultrastructurc, kidney, mouse. pp. 24-44. In: Urinary System (Jones, T. C., Mohr, U., and Hunt, R. D. eds.),Springer-Verlag, Berlin. Spanheimer, R. G., Umpierrez, G. E., and Stumpf, V. 1988. Decreased collagen production in diabetic rats. Diabetes 37: 371-376. Honjo, K., Doi, K., and Mitsuoka, T. 1986. Histopathology of streptozotocin-induced diabetic DBA/2N and CD-1 mice. Lab. Anim. 20: 298-303. Cortes, F., Dumler, F., Goldman, J., and Levin, N. W. 1987. Relationship between renal function and metabolic alterlations in early streptozotocin-induced diabetes in rats. Diabetes 36: 80-87. Sakaguchi, H. and Yamanaka, N. 1986. Renal disease. pp. 518-529. In: Electron Microscopic Diagnosis (The Committee of The Electron Microscopic Diagnosis Center, Nihon Medical College ed.), Fujita Kikaku Publications, Tokyo (in Japanese). Steffes, M. W., Brown, S. M., and Mauer, S. M. 1978. Diabetic glomerulopathy following unilateral nephrectomy in the rat. Diabetes 27: 35-41. |
| References_xml | – reference: Cortes, F., Dumler, F., Goldman, J., and Levin, N. W. 1987. Relationship between renal function and metabolic alterlations in early streptozotocin-induced diabetes in rats. Diabetes 36: 80-87. – reference: Sakaguchi, H. and Yamanaka, N. 1986. Renal disease. pp. 518-529. In: Electron Microscopic Diagnosis (The Committee of The Electron Microscopic Diagnosis Center, Nihon Medical College ed.), Fujita Kikaku Publications, Tokyo (in Japanese). – reference: Steffes, M. W., Brown, S. M., and Mauer, S. M. 1978. Diabetic glomerulopathy following unilateral nephrectomy in the rat. Diabetes 27: 35-41. – reference: Honjo, K., Doi, K., and Mitsuoka, T. 1986. Histopathology of streptozotocin-induced diabetic DBA/2N and CD-1 mice. Lab. Anim. 20: 298-303. – reference: Liebert, A. G. 1986. Unique feature of anatomy, histology, and ultrastructurc, kidney, mouse. pp. 24-44. In: Urinary System (Jones, T. C., Mohr, U., and Hunt, R. D. eds.),Springer-Verlag, Berlin. – reference: Like, A. A., Appel, M. C., Williams, R. M., and Possini, A. A. 1978. Streptozotocin-induced pancreatic insulitis in mice. Morphologic and physiologic studies. Lab. Invest. 38: 470-486. – reference: Steffes, M. W. and Mauer, S. M. 1984. Diabetic Glomerulopathy in man and experimental models. Int. Review of Exp. Pathol. 26: 147-175. – reference: Spanheimer, R. G., Umpierrez, G. E., and Stumpf, V. 1988. Decreased collagen production in diabetic rats. Diabetes 37: 371-376. – reference: Iwase, M., Kikuchi, M., Nunoi, K., Wakisaka, M., Maki, Y., Sadoshima, S., and Fujishima M. 1986. A new model of type 2 (non-insulin-dependent) diabetes induced by neonatal streptozotocin treatment. Diabetrogia 29: 808-811. – reference: Jakobson, J., Sidenius, P., Gunderson, H. J. G., and Osterby, R. 1987. Quantitive changes of cerebral neocortical structure in insulin-treated long-term streptozotocin-induced diabetes in rats. Diabetes 36: 597-601. |
| SSID | ssj0021469 ssib003110703 ssib003157696 ssib023157377 ssib003171049 ssib017579916 |
| Score | 1.4157771 |
| Snippet | あらかじめ片腎を摘出したマウスにストレプトゾトシン(SZ)を投与(50mg/kg/day×5days)することにより糖尿病を誘発した. SZ投与終了後4週おきに剖検を行い, 12週後(12WAI)まで検索を行った. 片腎摘出糖尿病マウスでは4WAIからメサンジウム領域の拡張が認められ,... |
| SourceID | affrit jstage |
| SourceType | Open Access Repository Publisher |
| StartPage | 1085 |
| Title | 片腎摘出糖尿病誘発マウスに於ける腎糸球体病変の検索 |
| URI | https://www.jstage.jst.go.jp/article/jvms1991/54/6/54_6_1085/_article/-char/ja https://agriknowledge.affrc.go.jp/RN/2010480405 |
| Volume | 54 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Journal of Veterinary Medical Science, 1992/12/15, Vol.54(6), pp.1085-1090 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Na9RAFA-1XryIVsX6RQ_OMWs-ZiaZi5DsplSLnlrpLSTZpLhgW2rrwVtbSimCWIRaQTxI8aAgQj1oUfxjYpte_B98b2a2iVDBKixh-vKb9znZmUnfvDWM627qdH2LFmY3yV2Tpl5upjSnpiMo9byEwaCRCbJ3-dgkvT3FpgZO_GxkLS0upK3s8ZHnSv4lqkCDuOIp2WNE9pApEKAN8YUrRBiufxVjEnnEFwT285FPfEb8iEScCJsIn0QM6WGAmNAlgiMltEg4ihThIR56BYEEA0VIsEt8AEey4ZCA60YoZMMmQShFcBK2NQXEKYwfNtSQQkPF2UKeESVhhwi3IZ2RgKL-mrNUHiiiLbtTEjh_WDrfwxwedZC4_48m_R3VHz9SyY40lqE5gYtjCalaP4rK-VaNp2gjagWibVRe4n20Cv7G2yG0a7wgAvzpSa-CpVzhmbRWyAZ4pF3jGdolpD7ADwRpvN_peycELeuXMJiwe_jASCC4S3pGgCIyrOCrMJKcsSsah4FmklkAH2kv-DpgstHW_UEiooFjG4ViGDoy0hSDKoLm21ubm56java2cjV3udQzcX_ZnNxUhW79EDdnKjx10lj1YH7ukTOqI7BCb-_Rg4ctRlt1r99qlOsnIEYY5tLFjMZcXbBH3L-PJwnjHmxnTjqeZ2MGbufW-OH7EZi0VWlMbZs-pwIa3GjKh7ViUhTz93En2IMtVD_9Uq4IJ84Yp_V4HAmU1LPGQD4zZAzVY3Pkjs5bOWeMV-trB6tP9ze29tZ2q53NvY_fqxerB--2qpe75crrcvltufylXHq_v_m1XNool58AuNr5XD1b-fHtOSD3ttfLpQ_726-qT2_OG5Oj0UR7zNQ_Y2ImYKVlFi7WaUvdLHVsznPLyTzWBVMLmiQJ9TLKWepj3TyawuLQy60ucznlBSwjfdcTiXvBGJyZnckvGiNFkSV57ljcyW1KszTNYUdBLWoXKezDmDNsWMo1cTI9X7-Vj2UNebiRxdOzcW8utuwYy8S6ts2HjZvKifGcKm8THzOYl_6XwWXjlMqBx_eaV4zBhfnF_Cqs9BfSa3J8_AL3ytpi |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%89%87%E8%85%8E%E6%91%98%E5%87%BA%E7%B3%96%E5%B0%BF%E7%97%85%E8%AA%98%E7%99%BA%E3%83%9E%E3%82%A6%E3%82%B9%E3%81%AB%E6%96%BC%E3%81%91%E3%82%8B%E8%85%8E%E7%B3%B8%E7%90%83%E4%BD%93%E7%97%85%E5%A4%89%E3%81%AE%E6%A4%9C%E7%B4%A2&rft.jtitle=Journal+of+Veterinary+Medical+Science&rft.au=%E6%9D%BF%E5%9E%A3%2C+%E6%85%8E%E4%B8%80&rft.au=%E4%B9%85%E7%B1%B3%2C+%E8%8B%B1%E4%BB%8B&rft.au=%E9%95%B7%E5%B3%B6%2C+%E5%90%89%E5%92%8C&rft.au=%E5%9C%9F%E5%B1%85%2C+%E5%8D%83%E4%BB%A3&rft.date=1992&rft.pub=%E5%85%AC%E7%9B%8A%E7%A4%BE%E5%9B%A3%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E7%8D%A3%E5%8C%BB%E5%AD%A6%E4%BC%9A&rft.issn=0916-7250&rft.eissn=1347-7439&rft.volume=54&rft.issue=6&rft.spage=1085&rft.epage=1090&rft_id=info:doi/10.1292%2Fjvms.54.1085&rft.externalDocID=article_jvms1991_54_6_54_6_1085_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0916-7250&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0916-7250&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0916-7250&client=summon |