Modern Palladium-Catalyzed Transformations Involving C–H Activation and Subsequent Annulation

The metal-catalyzed “cascade C–H activation/annulation” is a highly promising approach to the construction of aromatic and heteroaromatic compounds. In this context, Pd-complexes play a crucial role whereby molecules bearing a directing group can be activated with high catalytic efficiency. These re...

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Published inACS catalysis Vol. 12; no. 9; pp. 5217 - 5230
Main Authors Thombal, Raju S, Rubio, Peter Yuosef M, Lee, Daesung, Maiti, Debabrata, Lee, Yong Rok
Format Journal Article
LanguageEnglish
Published American Chemical Society 06.05.2022
Subjects
coupling
palladium
aromatics
annulation
C−H activation
heterocycles
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Summary:The metal-catalyzed “cascade C–H activation/annulation” is a highly promising approach to the construction of aromatic and heteroaromatic compounds. In this context, Pd-complexes play a crucial role whereby molecules bearing a directing group can be activated with high catalytic efficiency. These reactions will expand the synthetic potential of Pd-catalyzed C–H activation and subsequent aromatic and aliphatic C–C bond formation. Described herein is an outline of the recent advances in this research subject.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.2c00813