Neonatal Meningitis: The Ventricle as a Bacterial Reservoir

• We reviewed autopsies of neonates who had died of meningitis. Plexitis and ventricular exudate were usually present. While the pathogenetic relationship between these two phenomena is uncertain, it is possible that the glycogen-rich choroid plexus of the lateral ventricles not only facilitates loc...

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Bibliographic Details
Published inArchives of neurology (Chicago) Vol. 34; no. 9; pp. 560 - 562
Main Authors Gilles, Floyd H, Jammes, Juan L, Berenberg, William
Format Journal Article
LanguageEnglish
Published United States American Medical Association 01.09.1977
Subjects
Bacterial Infections - pathology
Cerebral Ventricles - microbiology
Cerebral Ventricles - pathology
Choroid Plexus - pathology
Exudates and Transudates - microbiology
Humans
Infant, Newborn
Infant, Newborn, Diseases - microbiology
Infant, Newborn, Diseases - pathology
Meningitis - microbiology
Meningitis - pathology
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Summary:• We reviewed autopsies of neonates who had died of meningitis. Plexitis and ventricular exudate were usually present. While the pathogenetic relationship between these two phenomena is uncertain, it is possible that the glycogen-rich choroid plexus of the lateral ventricles not only facilitates local bacterial growth but also acts as a bacterial reservoir relatively resistant to antimicrobial agents. We suggest that more drastic approaches than parenteral antimicrobial therapy may be indicated to reduce further the morbidity and mortality of neonatal meningitis.
Bibliography:ObjectType-Article-1
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ISSN:0003-9942
1538-3687
DOI:10.1001/archneur.1977.00500210062011