PhosphinooxazolinesA New Class of Versatile, Modular P,N-Ligands for Asymmetric Catalysis

Chiral phosphinooxazolines (PHOX ligands), which coordinate to a metal center with a N- and a P-atom, allow effective enantiocontrol in a variety of metal-catalyzed reactions. They are readily synthesized, and because of their modular structure, the steric and electronic properties can be tailored f...

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Bibliographic Details
Published inAccounts of chemical research Vol. 33; no. 6; pp. 336 - 345
Main Authors Helmchen, Günter, Pfaltz, Andreas
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.06.2000
Subjects
Catalysis
Ligands
Molecular Conformation
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organophosphorus Compounds - chemical synthesis
Organophosphorus Compounds - chemistry
Oxazoles - chemical synthesis
Oxazoles - chemistry
Palladium - chemistry
Phosphines - chemical synthesis
Phosphines - chemistry
Rubidium - chemistry
Stereoisomerism
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Summary:Chiral phosphinooxazolines (PHOX ligands), which coordinate to a metal center with a N- and a P-atom, allow effective enantiocontrol in a variety of metal-catalyzed reactions. They are readily synthesized, and because of their modular structure, the steric and electronic properties can be tailored for a specific application by variation of the oxazoline ring, the backbone, and the phosphine moiety.
Bibliography:ark:/67375/TPS-FDMVM2Q6-N
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ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0001-4842
1520-4898
DOI:10.1021/ar9900865