Dehydrogenative Cross-Coupling of α,β-Unsaturated Compounds with Unactivated Olefins via Co(III) Catalysis

An oxidative cross-coupling of α,β-unsaturated compounds with unactivated alkenes via cobalt-catalyzed vinylic C–H activation has been developed. The present catalytic reaction was examined with various differently functionalized unsaturated compounds and unactivated olefins. In these reactions, hig...

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Bibliographic Details
Published inOrganic letters Vol. 25; no. 34; pp. 6284 - 6289
Main Authors Logeswaran, Ravichandran, Jeganmohan, Masilamani
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 01.09.2023
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
OXIDATIVE OLEFINATION
FUNCTIONALIZATION
ACTIVATION
BONDS
C-H OLEFINATION
ELECTRON-DEFICIENT ALKENES
EFFICIENT
ACCESS
ALKENYLATION
AMIDES
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Summary:An oxidative cross-coupling of α,β-unsaturated compounds with unactivated alkenes via cobalt-catalyzed vinylic C–H activation has been developed. The present catalytic reaction was examined with various differently functionalized unsaturated compounds and unactivated olefins. In these reactions, highly valuable amide functionalized butadienes and indenones were prepared in good to excellent yields. A possible reaction mechanism is proposed involving directed olefinic C–H activation through a base-assisted deprotonation pathway.
Bibliography:ObjectType-Article-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c02095