Cracking the Code: Enhancing Molecular Tools for Progress in Nanobiotechnology

Nature continually refines its processes for optimal efficiency, especially within biological systems. This article explores the collaborative efforts of researchers worldwide, aiming to mimic nature’s efficiency by developing smarter and more effective nanoscale technologies and biomaterials. Recen...

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Published inACS applied bio materials Vol. 7; no. 6; pp. 3587 - 3604
Main Authors Avila, Yelixza I., Rebolledo, Laura P., Skelly, Elizabeth, de Freitas Saito, Renata, Wei, Hui, Lilley, David, Stanley, Robin E., Hou, Ya-Ming, Yang, Haoyun, Sztuba-Solinska, Joanna, Chen, Shi-Jie, Dokholyan, Nikolay V., Tan, Cheemeng, Li, S. Kevin, He, Xiaoming, Zhang, Xiaoting, Miles, Wayne, Franco, Elisa, Binzel, Daniel W., Guo, Peixuan, Afonin, Kirill A.
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 17.06.2024
Subjects
Biocompatible Materials - chemistry
Biotechnology
Drug Delivery Systems
Humans
Nanotechnology
Review
mRNA vaccines
RNA nanotechnology
nanobiotechnology
ISRNN
nanoparticles
nucleic acid therapies
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Summary:Nature continually refines its processes for optimal efficiency, especially within biological systems. This article explores the collaborative efforts of researchers worldwide, aiming to mimic nature’s efficiency by developing smarter and more effective nanoscale technologies and biomaterials. Recent advancements highlight progress and prospects in leveraging engineered nucleic acids and proteins for specific tasks, drawing inspiration from natural functions. The focus is developing improved methods for characterizing, understanding, and reprogramming these materials to perform user-defined functions, including personalized therapeutics, targeted drug delivery approaches, engineered scaffolds, and reconfigurable nanodevices. Contributions from academia, government agencies, biotech, and medical settings offer diverse perspectives, promising a comprehensive approach to broad nanobiotechnology objectives. Encompassing topics from mRNA vaccine design to programmable protein-based nanocomputing agents, this work provides insightful perspectives on the trajectory of nanobiotechnology toward a future of enhanced biomimicry and technological innovation.
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ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.4c00432