Neurobiology of Huntington's Disease Applications to Drug Discovery

Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, Neurobiology of Huntington's Disease focuses on the many aspects of the research on drugs to treat Huntington's disease. It discusses genetics, genomics, and proteomics, and the la...

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Bibliographic Details
Main Authors Lo, Donald C, Hughes, Robert E
Format eBook
LanguageEnglish
Published Milton CRC Press 2011
Taylor & Francis Group
Edition1
SeriesFrontiers in neuroscience
Subjects
Huntington's disease
Neuropharmacology
Htt Fragment
Hd Subject
Expand CAG Repeat
Mutant Huntingtin
Mutant Htt
Hd Model
Ef Cacy
CAG Expansion
Repeat Length
Transgenic Mouse
CAG Repeat Length
RVG Peptide
Hd Mouse
polyQ Disease
Manifest Hd
Hd Patient
Hd Therapy
CAG Repeat
Hd Pathogenesis
Wild Type Htt
Target Validation
Ef Cacy Studies
Antisense Oligonucleotide
Hd Mouse Model
Online AccessGet full text
ISBN0849390001
9780849390005
DOI10.1201/EBK0849390005

Cover

Table of Contents:
  • Front cover -- Contents -- Series Preface -- Preface -- Editors -- Contributors -- Chapter 1: Huntington's Disease -- Chapter 2: Huntington's Disease Pathogenesis -- Chapter 3: Protein Interactionsand Target Discovery inHuntington's Disease -- Chapter 4: Target Validation forHuntington's Disease -- Chapter 5: High-Throughput andHigh-Content Screeningfor Huntington'sDisease Therapeutics -- Chapter 6: Value of InvertebrateGenetics and Biology toDevelop Neuroprotectiveand Preventive Medicinein Huntington's Disease -- Chapter 7: Mouse Models forValidating PreclinicalCandidates forHuntington's Disease -- Chapter 8: PharmaceuticalDevelopment forHuntington's Disease -- Chapter 9: RNA- and DNABasedTherapies forHuntington's Disease -- Chapter 10: Recombinant Intrabodiesas Molecular Tools andPotential Therapeuticsfor Huntington's Disease -- Chapter 11: Biomarkers to Enablethe Developmentof NeuroprotectiveTherapies forHuntington's Disease -- Chapter 12: Huntington's Disease -- Index -- Color Inserts: -- Back cover