Neurobiology of Huntington's Disease Applications to Drug Discovery

Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, Neurobiology of Huntington's Disease focuses on the many aspects of the research on drugs to treat Huntington's disease. It discusses genetics, genomics, and proteomics, and the la...

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Bibliographic Details
Main Authors Lo, Donald C, Hughes, Robert E
Format eBook
LanguageEnglish
Published Milton CRC Press 2011
Taylor & Francis Group
Edition1
SeriesFrontiers in neuroscience
Subjects
Huntington's disease
Neuropharmacology
Htt Fragment
Hd Subject
Expand CAG Repeat
Mutant Huntingtin
Mutant Htt
Hd Model
Ef Cacy
CAG Expansion
Repeat Length
Transgenic Mouse
CAG Repeat Length
RVG Peptide
Hd Mouse
polyQ Disease
Manifest Hd
Hd Patient
Hd Therapy
CAG Repeat
Hd Pathogenesis
Wild Type Htt
Target Validation
Ef Cacy Studies
Antisense Oligonucleotide
Hd Mouse Model
Online AccessGet full text
ISBN0849390001
9780849390005
DOI10.1201/EBK0849390005

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Summary:Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, Neurobiology of Huntington's Disease focuses on the many aspects of the research on drugs to treat Huntington's disease. It discusses genetics, genomics, and proteomics, and the latest in high-throughput and high-content screening. The authors provide introductory background as well as highly sophisticated information on current and future directions of research. Exploring the interplay between academic and industrial research, the investment community, and non-profit contributors, the book also examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage.
ISBN:0849390001
9780849390005
DOI:10.1201/EBK0849390005