Neurobiology of Huntington's Disease Applications to Drug Discovery

Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, Neurobiology of Huntington's Disease focuses on the many aspects of the research on drugs to treat Huntington's disease. It discusses genetics, genomics, and proteomics, and the la...

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Bibliographic Details
Main Authors Lo, Donald C, Hughes, Robert E
Format eBook
LanguageEnglish
Published Milton CRC Press 2011
Taylor & Francis Group
Edition1
SeriesFrontiers in neuroscience
Subjects
Huntington's disease
Neuropharmacology
Htt Fragment
Hd Subject
Expand CAG Repeat
Mutant Huntingtin
Mutant Htt
Hd Model
Ef Cacy
CAG Expansion
Repeat Length
Transgenic Mouse
CAG Repeat Length
RVG Peptide
Hd Mouse
polyQ Disease
Manifest Hd
Hd Patient
Hd Therapy
CAG Repeat
Hd Pathogenesis
Wild Type Htt
Target Validation
Ef Cacy Studies
Antisense Oligonucleotide
Hd Mouse Model
Online AccessGet full text
ISBN0849390001
9780849390005
DOI10.1201/EBK0849390005

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Abstract Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, Neurobiology of Huntington's Disease focuses on the many aspects of the research on drugs to treat Huntington's disease. It discusses genetics, genomics, and proteomics, and the latest in high-throughput and high-content screening. The authors provide introductory background as well as highly sophisticated information on current and future directions of research. Exploring the interplay between academic and industrial research, the investment community, and non-profit contributors, the book also examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage.
AbstractList In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington's Disease: Applications to Drug Discoverypresents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families.
Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, Neurobiology of Huntington's Disease focuses on the many aspects of the research on drugs to treat Huntington's disease. It discusses genetics, genomics, and proteomics, and the latest in high-throughput and high-content screening. The authors provide introductory background as well as highly sophisticated information on current and future directions of research. Exploring the interplay between academic and industrial research, the investment community, and non-profit contributors, the book also examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage.
Author Lo, Donald C
Hughes, Robert E
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Keywords Htt Fragment
Hd Subject
Expand CAG Repeat
Mutant Huntingtin
Mutant Htt
Hd Model
Ef Cacy
CAG Expansion
Repeat Length
Transgenic Mouse
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RVG Peptide
Hd Mouse
polyQ Disease
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CAG Repeat
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Target Validation
Ef Cacy Studies
Antisense Oligonucleotide
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Snippet Highlighting advances in the discovery and development of new drug therapies for neurodegenerative disorders, Neurobiology of Huntington's Disease focuses on...
In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to...
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SubjectTerms Huntington's disease
Neuropharmacology
Subtitle Applications to Drug Discovery
TableOfContents Front cover -- Contents -- Series Preface -- Preface -- Editors -- Contributors -- Chapter 1: Huntington's Disease -- Chapter 2: Huntington's Disease Pathogenesis -- Chapter 3: Protein Interactionsand Target Discovery inHuntington's Disease -- Chapter 4: Target Validation forHuntington's Disease -- Chapter 5: High-Throughput andHigh-Content Screeningfor Huntington'sDisease Therapeutics -- Chapter 6: Value of InvertebrateGenetics and Biology toDevelop Neuroprotectiveand Preventive Medicinein Huntington's Disease -- Chapter 7: Mouse Models forValidating PreclinicalCandidates forHuntington's Disease -- Chapter 8: PharmaceuticalDevelopment forHuntington's Disease -- Chapter 9: RNA- and DNABasedTherapies forHuntington's Disease -- Chapter 10: Recombinant Intrabodiesas Molecular Tools andPotential Therapeuticsfor Huntington's Disease -- Chapter 11: Biomarkers to Enablethe Developmentof NeuroprotectiveTherapies forHuntington's Disease -- Chapter 12: Huntington's Disease -- Index -- Color Inserts: -- Back cover
Title Neurobiology of Huntington's Disease
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