Brain Lesions in Patients Visiting a Memory Clinic With Postconcussional Sequelae After Mild to Moderate Brain Injury

Postconcussional disorder after a relatively mild head injury is common. Although a partial organic etiology is presumed, little imaging evidence exists for this assumption. In this study, patients with mild to moderate brain injury (median Glasgow Coma Scale score of 14) had more parenchymal brain...

Full description

Saved in:
Bibliographic Details
Published inThe journal of neuropsychiatry and clinical neurosciences Vol. 14; no. 2; pp. 176 - 184
Main Authors Hofman, Paul A.M, Verhey, Frans R.J, Wilmink, Jan T, Rozendaal, Nico, Jolles, Jelle
Format Journal Article
LanguageEnglish
Published Washington, DC American Psychiatric Publishing 2002
American Psychiatric Press
Subjects
Adult
Biological and medical sciences
Brain - diagnostic imaging
Brain - pathology
Brain Concussion - complications
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Female
Glasgow Coma Scale
Humans
Injuries of the nervous system and the skull. Diseases due to physical agents
Magnetic Resonance Imaging
Male
Medical sciences
Memory Disorders - diagnosis
Memory Disorders - etiology
Middle Aged
Neuropsychological Tests
Tomography, X-Ray Computed
Traumas. Diseases due to physical agents
Human
Memory disorder
Nervous system diseases
Craniocerebral
Central nervous system
Diseases of the osteoarticular system
Contusion
Sequela
Cognition
Trauma
Cerebral disorder
Eye disease
Central nervous system disease
Skull disease
Lesion
Brain (vertebrata)
Online AccessGet full text

Cover

More Information
Summary:Postconcussional disorder after a relatively mild head injury is common. Although a partial organic etiology is presumed, little imaging evidence exists for this assumption. In this study, patients with mild to moderate brain injury (median Glasgow Coma Scale score of 14) had more parenchymal brain lesions than control subjects (P=0.02). Additionally, the authors investigated the potential of quantifying brain injury by the magnetization transfer ratio (MTR). The curve amplitude of the MTR histogram was used as a measure of normal white matter. Patients had a lower curve amplitude than control subjects (P=0.008). This study provides evidence of persistent traumatic brain alterations in patients who sustained a relatively mild traumatic brain injury.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.14.2.176