N-[(1-Butyl-4-piperidinyl)methyl]-3,4- dihydro-2H-[1,3]oxazino[3,2-a]indole- 10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 38; no. 24; pp. 4760 - 4763
Main Authors Gaster, Laramie M, Joiner, Graham F, King, Frank D, Wyman, Paul A, Sutton, Jonathan M, Bingham, Sharon, Ellis, Elizabeth S, Sanger, Gareth J, Wardle, Kay A
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 01.11.1995
Amer Chemical Soc
Subjects
Biological and medical sciences
Chemistry, Medicinal
Life Sciences & Biomedicine
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Science & Technology
Serotoninergic system
RADIOLIGAND
GUINEA-PIG
Fissipedia
Carnivora
Oral administration
Tricyclic compound
In vitro
In vivo
Vertebrata
Mammalia
Structure activity relation
Hydrochlorides
Animal
Piperidine derivatives
5-HT4 receptor
Carboxamide
Aromatic compound
Antagonist
Chemical synthesis
Dog
Oxygen nitrogen heterocycle
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Bibliography:istex:28A81BC4A17D4A57BB0E32622F0C44DB24F244E5
ark:/67375/TPS-BHDBSTBV-C
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00024a002