Partial Volumes of Phosphatidylcholines and Vitamin E: α‑Tocopherol Prefers Disordered Membranes

Despite its discovery over 95 years ago, the biological and nutritional roles of vitamin E remain subjects of much controversy. Though it is known to possess antioxidant properties, recent assertions have implied that vitamin E may not be limited to this function in living systems. Through densitome...

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Published inThe journal of physical chemistry. B Vol. 126; no. 35; pp. 6691 - 6699
Main Authors DiPasquale, Mitchell, Nguyen, Michael H. L., Pabst, Georg, Marquardt, Drew
Format Journal Article
LanguageEnglish
Published American Chemical Society 08.09.2022
Subjects
alpha-tocopherol
antioxidants
B: Biomaterials and Membranes
densitometry
oxygen
phosphatidylcholines
physical chemistry
small-angle X-ray scattering
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Summary:Despite its discovery over 95 years ago, the biological and nutritional roles of vitamin E remain subjects of much controversy. Though it is known to possess antioxidant properties, recent assertions have implied that vitamin E may not be limited to this function in living systems. Through densitometry measurements and small-angle X-ray scattering we observe favorable interactions between α-tocopherol and unsaturated phospholipids, with more favorable interactions correlating to an increase in lipid chain unsaturation. Our data provide evidence that vitamin E may preferentially associate with oxygen sensitive lipidsan association that is considered innate for a viable membrane antioxidant.
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ISSN:1520-6106
1520-5207
1520-5207
DOI:10.1021/acs.jpcb.2c04209