Rhodium(I)-Catalyzed Coupling–Cyclization of CO Bonds with α‑Diazoketones

An unprecedented intermolecular nucleophilic attack of CX bonds (X = O and S) on the rhodium­(I)-carbenes has been developed. This transformation allows for the coupling–cyclization of aroylamides with α-diazoketones and provides concise access to 2,4,5-trisubstituted 1,3-oxazoles and 1,3-thiazoles...

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Published inOrganic letters Vol. 20; no. 13; pp. 3980 - 3983
Main Authors Chen, Ziyang, Hu, Xinwei, Huang, Junmin, Zeng, Wei
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 06.07.2018
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Summary:An unprecedented intermolecular nucleophilic attack of CX bonds (X = O and S) on the rhodium­(I)-carbenes has been developed. This transformation allows for the coupling–cyclization of aroylamides with α-diazoketones and provides concise access to 2,4,5-trisubstituted 1,3-oxazoles and 1,3-thiazoles with a broad tolerance of functional groups.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b01541