Manganese-Catalyzed Directed Methylation of C(sp2)–H Bonds at 25 °C with High Catalytic Turnover

We report here a manganese-catalyzed C–H methylation reaction of considerable substrate scope, using MeMgBr, a catalytic amount of MnCl2·2LiCl, and an organic dihalide oxidant. The reaction features ambient temperature, low catalyst loading, typically 1%, high catalytic turnover reaching 5.9 × 103,...

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Bibliographic Details
Published inOrganic letters Vol. 19; no. 19; pp. 5458 - 5461
Main Authors Sato, Takenari, Yoshida, Takumi, Al Mamari, Hamad H, Ilies, Laurean, Nakamura, Eiichi
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 06.10.2017
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Summary:We report here a manganese-catalyzed C–H methylation reaction of considerable substrate scope, using MeMgBr, a catalytic amount of MnCl2·2LiCl, and an organic dihalide oxidant. The reaction features ambient temperature, low catalyst loading, typically 1%, high catalytic turnover reaching 5.9 × 103, and no need for an extraneous ligand and illustrates a unique catalytic use of simple manganese salts for C–H activation, which so far has relied on catalysis by manganese carbonyls.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b02778