Manganese-Catalyzed Directed Methylation of C(sp2)–H Bonds at 25 °C with High Catalytic Turnover
We report here a manganese-catalyzed C–H methylation reaction of considerable substrate scope, using MeMgBr, a catalytic amount of MnCl2·2LiCl, and an organic dihalide oxidant. The reaction features ambient temperature, low catalyst loading, typically 1%, high catalytic turnover reaching 5.9 × 103,...
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Published in | Organic letters Vol. 19; no. 19; pp. 5458 - 5461 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
06.10.2017
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Online Access | Get full text |
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Summary: | We report here a manganese-catalyzed C–H methylation reaction of considerable substrate scope, using MeMgBr, a catalytic amount of MnCl2·2LiCl, and an organic dihalide oxidant. The reaction features ambient temperature, low catalyst loading, typically 1%, high catalytic turnover reaching 5.9 × 103, and no need for an extraneous ligand and illustrates a unique catalytic use of simple manganese salts for C–H activation, which so far has relied on catalysis by manganese carbonyls. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/acs.orglett.7b02778 |