T 1 and T 2 Dual-Mode MRI Contrast Agent for Enhancing Accuracy by Engineered Nanomaterials

One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here,...

Full description

Saved in:
Bibliographic Details
Published inACS nano Vol. 8; no. 4; pp. 3393 - 3401
Main Authors Shin, Tae-Hyun, Choi, Jin-sil, Yun, Seokhwan, Kim, Il-Sun, Song, Ho-Taek, Kim, Youngmee, Park, Kook In, Cheon, Jinwoo
Format Journal Article
LanguageEnglish
Published American Chemical Society 22.04.2014
Subjects
magnetic nanoparticle
MRI contrast agent
stem cell tracking
dual-mode contrast agent
MRI
Online AccessGet full text

Cover

More Information
Summary:One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform “AND logic gate” algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.
ISSN:1936-0851
1936-086X
DOI:10.1021/nn405977t