Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation

A practical synthesis of a macrocyclic HCV protease inhibitor, MK-1220, is described. The key features are a new synthesis of the trisubstituted isoquinoline, Sonogashira fragment coupling, and a high-yielding, 18-membered macrolactam formation.

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Bibliographic Details
Published inOrganic process research & development Vol. 18; no. 3; pp. 423 - 430
Main Authors Song, Zhiguo J, Tellers, David M, Dormer, Peter G, Zewge, Daniel, Janey, Jacob M, Nolting, Andrew, Steinhuebel, Dietrich, Oliver, Steven, Devine, Paul N, Tschaen, David M
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 21.03.2014
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Applied
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:A practical synthesis of a macrocyclic HCV protease inhibitor, MK-1220, is described. The key features are a new synthesis of the trisubstituted isoquinoline, Sonogashira fragment coupling, and a high-yielding, 18-membered macrolactam formation.
ISSN:1083-6160
1520-586X
DOI:10.1021/op400331j