Hydrogen Peroxide Oxidation of Phosphite Triesters in Oligonucleotide Syntheses

The oxidation of P(III) phosphite triesters to stable P(V) phosphates in oligonucleotide syntheses using hydrogen peroxide was demonstrated in neutral aqueous acetonitrile as a cheap, green alternative to the widely used iodine pyridine procedure. This oxidation was utilized on short oligomers of tw...

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Published inOrganic process research & development Vol. 14; no. 1; pp. 295 - 297
Main Author Cvetovich, Raymond J
Format Journal Article
LanguageEnglish
Published American Chemical Society 15.01.2010
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Abstract The oxidation of P(III) phosphite triesters to stable P(V) phosphates in oligonucleotide syntheses using hydrogen peroxide was demonstrated in neutral aqueous acetonitrile as a cheap, green alternative to the widely used iodine pyridine procedure. This oxidation was utilized on short oligomers of two nucleosides.
AbstractList The oxidation of P(III) phosphite triesters to stable P(V) phosphates in oligonucleotide syntheses using hydrogen peroxide was demonstrated in neutral aqueous acetonitrile as a cheap, green alternative to the widely used iodine pyridine procedure. This oxidation was utilized on short oligomers of two nucleosides.
Author Cvetovich, Raymond J
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Cites_doi 10.1016/j.tetlet.2006.10.016
10.1039/b404932m
10.1038/nmeth911
10.1073/pnas.0306111101
10.1016/S0960-894X(03)00754-6
10.1021/ol000364w
10.1021/ol9910518
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10.1016/S0040-4039(00)98437-5
10.1016/S0040-4020(01)87958-8
10.1021/ja030376n
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Copyright Copyright © 2009 American Chemical Society
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Title Hydrogen Peroxide Oxidation of Phosphite Triesters in Oligonucleotide Syntheses
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