Hydrogen Peroxide Oxidation of Phosphite Triesters in Oligonucleotide Syntheses
The oxidation of P(III) phosphite triesters to stable P(V) phosphates in oligonucleotide syntheses using hydrogen peroxide was demonstrated in neutral aqueous acetonitrile as a cheap, green alternative to the widely used iodine pyridine procedure. This oxidation was utilized on short oligomers of tw...
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| Published in | Organic process research & development Vol. 14; no. 1; pp. 295 - 297 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
American Chemical Society
15.01.2010
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| Online Access | Get full text |
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| Summary: | The oxidation of P(III) phosphite triesters to stable P(V) phosphates in oligonucleotide syntheses using hydrogen peroxide was demonstrated in neutral aqueous acetonitrile as a cheap, green alternative to the widely used iodine pyridine procedure. This oxidation was utilized on short oligomers of two nucleosides. |
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| ISSN: | 1083-6160 1520-586X |
| DOI: | 10.1021/op900044z |