Synthesis of 2-Methyl-2,5-diazabicyclo[2.2.1]heptane, Side Chain to Danofloxacin
Various syntheses of the side chain of the quinolone antibiotic danofloxacin are described. The realization that the N-methyl substitution on the side chain 2-methyl-2,5-diazabicyclo[2.2.1]heptane can reside on either nitrogen, due to the symmetry of the molecule, played a major role in the design o...
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| Published in | Organic process research & development Vol. 13; no. 2; pp. 336 - 340 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
American Chemical Society
20.03.2009
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| Online Access | Get full text |
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| Summary: | Various syntheses of the side chain of the quinolone antibiotic danofloxacin are described. The realization that the N-methyl substitution on the side chain 2-methyl-2,5-diazabicyclo[2.2.1]heptane can reside on either nitrogen, due to the symmetry of the molecule, played a major role in the design of the commercial synthetic route. |
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| ISSN: | 1083-6160 1520-586X |
| DOI: | 10.1021/op8002618 |