Palladium-Catalyzed Direct Dehydrogenative Annulation of Ferrocenecarboxamides with Alkynes in Air

A novel method to synthesize racemic ferrocene[1,2-c]pyridine-3(4H)-ones via Pd-catalyzed direct dehydrogenative annulations of ferrocenecarboxamides with internal alkynes in air has been developed. Both alkyl and aryl ferrocenecarboxamides can be applied as effective substrates.

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Bibliographic Details
Published inOrganometallics Vol. 33; no. 9; pp. 2138 - 2141
Main Authors Xie, Wucheng, Li, Bin, Xu, Shansheng, Song, Haibin, Wang, Baiquan
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 12.05.2014
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Physical Sciences
Science & Technology
H BOND ACTIVATION
ENANTIOSELECTIVE SYNTHESIS
HIGHLY SUBSTITUTED NAPHTHALENES
RUTHENIUM
PLANAR CHIRAL FERROCENES
OXIDATIVE ANNULATION
HECK REACTION
INDOLES
C-H
ISOQUINOLINIUM SALTS
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Summary:A novel method to synthesize racemic ferrocene[1,2-c]pyridine-3(4H)-ones via Pd-catalyzed direct dehydrogenative annulations of ferrocenecarboxamides with internal alkynes in air has been developed. Both alkyl and aryl ferrocenecarboxamides can be applied as effective substrates.
ISSN:0276-7333
1520-6041
DOI:10.1021/om5002606