Calcium Pantothenate. Part 3. Process for the Biologically Active Enantiomer of the Same via Selective Crystallization and Racemization

Optically pure calcium (R)-pantothenate has been obtained from the racemic compound via direct fractional crystallization of the single enantiomer. Efficient racemization of the biologically inactive calcium (S)-pantothenate without its decomposition to pantolactone has been developed, resulting in...

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Published inOrganic process research & development Vol. 12; no. 6; pp. 1238 - 1244
Main Authors Synoradzki, Ludwik, Hajmowicz, Halina, Wisialski, Jerzy, Mizerski, Arkadiusz, Rowicki, Tomasz
Format Journal Article
LanguageEnglish
Published American Chemical Society 21.11.2008
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Summary:Optically pure calcium (R)-pantothenate has been obtained from the racemic compound via direct fractional crystallization of the single enantiomer. Efficient racemization of the biologically inactive calcium (S)-pantothenate without its decomposition to pantolactone has been developed, resulting in a simple, complete, and efficient technology. The results elaborated in the laboratory have been then successfully applied in the industrial scale process.
ISSN:1083-6160
1520-586X
DOI:10.1021/op800189g