Process Development and Scale-Up of AZD7545, a PDK Inhibitor

A brief comparison of the early manufacturing routes to AZD7545 is given. Process development of the preferred long-term manufacturing route is reported in detail, and changes from the initial kilogram-scale route are discussed. Scale-up experience from the pilot-plant manufacture is included in the...

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Published inOrganic process research & development Vol. 16; no. 3; pp. 447 - 460
Main Authors Patel, Bharti, Firkin, Catherine R, Snape, Evan W, Jenkin, Shelley L, Brown, David, Chaffey, Julian G. K, Hopes, Philip A, Reens, Carl D, Butters, Mike, Moseley, Jonathan D
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 16.03.2012
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Applied
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:A brief comparison of the early manufacturing routes to AZD7545 is given. Process development of the preferred long-term manufacturing route is reported in detail, and changes from the initial kilogram-scale route are discussed. Scale-up experience from the pilot-plant manufacture is included in the discussion of each stage. Noteworthy aspects throughout the development of AZD7545 concerned chemical hazards, mechanisms, analysis, and impurities, upon which this case study will focus.
ISSN:1083-6160
1520-586X
DOI:10.1021/op2003419