Synthesis and Process Optimization of Amtolmetin: An Antiinflammatory Agent

Efforts toward the synthesis and process optimization of amtolmetin guacil 1 are described. High-yielding electrophilic substitution followed by Wolf−Kishner reduction are the key features in the novel synthesis of tolmetin 2 which is an advanced intermediate of 1.

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Bibliographic Details
Published inOrganic process research & development Vol. 14; no. 2; pp. 362 - 368
Main Authors Reddy, Lekkala Amarnath, Chakraborty, Saurya, Swapna, Rodda, Bhalerao, Dinesh, Malakondaiah, Golla China, Ravikumar, Mylavarapu, Kumar, Abhijeet, Reddy, Gade Srinivas, Naram, Jyothirmayi, Dwivedi, Namrata, Roy, Arnab, Himabindu, Vurimidi, Babu, Bangaru, Bhattacharya, Apurba, Bandichhor, Rakeshwar
Format Journal Article
LanguageEnglish
Published American Chemical Society 19.03.2010
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Summary:Efforts toward the synthesis and process optimization of amtolmetin guacil 1 are described. High-yielding electrophilic substitution followed by Wolf−Kishner reduction are the key features in the novel synthesis of tolmetin 2 which is an advanced intermediate of 1.
ISSN:1083-6160
1520-586X
DOI:10.1021/op900284w