An Alternative Method to Isolate Pharmaceutical Intermediates

A robust crystallisation process can be resource intensive to develop, but simpler isolation alternatives such as evaporation to dryness can have thermal stability issues and result in a difficult to handle solid residue. This contribution presents Solid Supported Evaporation as an equally simple al...

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Bibliographic Details
Published inOrganic process research & development Vol. 15; no. 1; pp. 84 - 90
Main Authors Muller, Frans L, Whitlock, Brian
Format Journal Article
LanguageEnglish
Published American Chemical Society 21.01.2011
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Summary:A robust crystallisation process can be resource intensive to develop, but simpler isolation alternatives such as evaporation to dryness can have thermal stability issues and result in a difficult to handle solid residue. This contribution presents Solid Supported Evaporation as an equally simple alternative to evaporation to dryness but which goes some way to overcome the thermal stability issue and results in an easy to handle solid product.
ISSN:1083-6160
1520-586X
DOI:10.1021/op100207e