The Vaporization Enthalpies and Vapor Pressures of Some Primary Amines of Pharmaceutical Importance by Correlation Gas Chromatography

• Published in: Journal of chemical and engineering data Vol. 58; no. 9; pp. 2600 - 2609
• Main Authors: Gobble, Chase, Rath, Nigam, Chickos, James
• Format: Journal Article
• Language: English
• Published: American Chemical Society 12.09.2013
• ISSN: 0021-9568; 1520-5134
• DOI: 10.1021/je400498a

Vapor pressures, vaporization, and sublimation enthalpies of several pharmaceuticals have been evaluated by a combination of correlation chromatography experiments, differential calorimetry measurements with existing literature values. The compounds investigated and their properties include 1-adamantylamine [Δcr l H m(T fus)/kJ·mol–1 = (7.3 ± 0.2); T fus/K = (477.4 ± 0.9); Δl g H m(298.15 K)/kJ·mol–1 = (59.9 ± 2.5); Δcr g H m(298.15 K)/kJ·mol–1 = (∼59.9 ± 3.5); p (l)/Pa = (21 ± 1); p (cr)/Pa = (11.5 ± 2.1)]; 1-adamantyl-ethanamine, [Δl g H m(298.15 K)/kJ·mol–1 = (68.7 ± 3.7); p (l)/Pa = (3 ± 1)]; α,α-dimethylphenethylamine [Δl g H m(298.15 K)/kJ·mol–1 = (60.2 ± 2.6); p (l)/Pa = (35 ± 4)]; trans 2-phenylcyclopropylamine [Δl g H m(298.15 K)/kJ·mol–1 = (60.3 ± 2.1), p (l)/Pa = (28 ± 5)]; 1-dodecanamine [Δcr g H m(298.15 K)/kJ·mol–1 = (118.3 ± 1.8); p (cr)/Pa = 1.6 ± 0.1]; and 1-tetradecanamine [Δcr g H m(298.15 K)/kJ·mol–1 = (134.5 ± 2.1); p (cr)/Pa = 0.12 ± 0.04]. Vapor pressure equations also derived from vapor pressureretention time correlations as a function of temperature are reported for both standards and targets. The equations appear applicable from T/K = 298.15 to each compound’s respective boiling temperature.