Development of a Large-Scale Synthetic Route to Manufacture (−)-Huperzine A

A safe, practical and scalable process for manufacture of (−)-huperzine A has been developed and scaled up to manufacture several hundred grams of (−)-huperzine A with chemical and optical purity of >99%. The process consists of 11 chemical stages starting from commercially available materials wi...

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Bibliographic Details
Published inOrganic process research & development Vol. 16; no. 4; pp. 635 - 642
Main Authors Tudhope, Stephen R, Bellamy, Julie A, Ball, Anthony, Rajasekar, Dewakar, Azadi-Ardakani, Manouchehr, Meera, Harihara Subramanian, Gnanadeepam, Jesudoss Mercy, Saiganesh, Ramanathan, Gibson, Frank, He, Linli, Behrens, Carl H, Underiner, Gail, Marfurt, Judith, Favre, Nathalie
Format Journal Article
LanguageEnglish
Published American Chemical Society 20.04.2012
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Summary:A safe, practical and scalable process for manufacture of (−)-huperzine A has been developed and scaled up to manufacture several hundred grams of (−)-huperzine A with chemical and optical purity of >99%. The process consists of 11 chemical stages starting from commercially available materials with only nine isolation steps and no chromatography purification. This process provides a reliable and cost-effective source of synthetic (−)-huperzine A and its derivatives for pharmaceutical and nutraceutical markets.
ISSN:1083-6160
1520-586X
DOI:10.1021/op200360b