Integrated Approach to the Development and Understanding of the Borane Reduction of a Carboxylic Acid

A delayed exotherm was recorded during the reduction of a carboxylic acid with BH3·THF. This article will describe our efforts to explain and control the observed exotherm using a reactor integrated with a mass-flow meter, a reaction calorimeter, and an in situ FT-IR probe. In the end, a kinetic mod...

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Bibliographic Details
Published inOrganic process research & development Vol. 8; no. 6; pp. 1072 - 1075
Main Authors Lobben, Paul C, Leung, Simon Shun-Wang, Tummala, Srinivas
Format Journal Article
LanguageEnglish
Published American Chemical Society 01.11.2004
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Summary:A delayed exotherm was recorded during the reduction of a carboxylic acid with BH3·THF. This article will describe our efforts to explain and control the observed exotherm using a reactor integrated with a mass-flow meter, a reaction calorimeter, and an in situ FT-IR probe. In the end, a kinetic model is proposed that allows control of the addition rate of the reagent based on the known cooling capacity of the reaction vessel.
ISSN:1083-6160
1520-586X
DOI:10.1021/op049910h