Alternate Synthesis of a β-3 Adrenergic Receptor Agonist

Previously our group reported synthetic efforts used to synthesize kilogram quantities of the β-3 receptor agonist (R)-(4-(2-(2-(6-aminopyridin-3-yl)-2-hydroxyethylamino)ethoxy)phenyl)acetic acid, 1. Additional research was conducted to explore an alternate chiral route with a streamlined protecting...

Full description

Saved in:
Bibliographic Details
Published inOrganic process research & development Vol. 8; no. 4; pp. 587 - 592
Main Authors Scott, Robert W., Fox, Darrell E., Wong, John W., Burns, Michael P.
Format Journal Article
LanguageEnglish
Published American Chemical Society 01.07.2004
Online AccessGet full text

Cover

More Information
Summary:Previously our group reported synthetic efforts used to synthesize kilogram quantities of the β-3 receptor agonist (R)-(4-(2-(2-(6-aminopyridin-3-yl)-2-hydroxyethylamino)ethoxy)phenyl)acetic acid, 1. Additional research was conducted to explore an alternate chiral route with a streamlined protecting group scheme. The alternate asymmetric process and synthetic rationale are described.
ISSN:1083-6160
1520-586X
DOI:10.1021/op0499775