In vivo inhibition of inducible nitric oxide and evaluation of the brain tissue damage induced by Toxocara canis larvae in experimentally infected mice

Nitric oxide (NO) is known to be produced by macrophages, endothelial cells and neurons and synthesized by an enzyme called nitric oxide synthase (NOS). Various effector mechanisms and infections can affect the NO production. Excessive amount of NO will lead to biochemical reactions, which cause tox...

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Published inChinese journal of physiology Vol. 47; no. 4; p. 189
Main Authors Gargili, Aysen, Demirci, Cihan, Kandil, Asli, Cetinkaya, Handan, Atukeren, Pinar, Gümüştaş, M Koray
Format Journal Article
LanguageEnglish
Published India 31.12.2004
Subjects
Animals
Brain - enzymology
Brain - pathology
Enzyme Inhibitors - pharmacology
Enzyme Inhibitors - therapeutic use
Guanidines - pharmacology
Guanidines - therapeutic use
Histocytochemistry
Larva
Lipid Peroxidation - drug effects
Mice
Mice, Inbred BALB C
NADPH Dehydrogenase - metabolism
Nitric Oxide Synthase - antagonists & inhibitors
Nitric Oxide Synthase Type II
Oxidative Stress - drug effects
Superoxide Dismutase - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
Toxocara canis
Toxocariasis - drug therapy
Toxocariasis - parasitology
Toxocariasis - pathology
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Summary:Nitric oxide (NO) is known to be produced by macrophages, endothelial cells and neurons and synthesized by an enzyme called nitric oxide synthase (NOS). Various effector mechanisms and infections can affect the NO production. Excessive amount of NO will lead to biochemical reactions, which cause toxic effects. In this study the role of NO has been evaluated in larval toxocarosis, which is a systemic parasite infection caused by T. canis larvae. Infection was established in the Balb/c mice with or without inducible NOS (iNOS) inhibition and the effects of infection and NOS inhibition were observed according to the results of SOD and LPx measurements in brain tissue and NADPH-diaphorase (NADP-d) histochemistry. Results of NADPH-d histochemistry indicate that iNOS inhibition has protective effect on the brains of infected mice and that larval T. canis infection could be related to oxidative stress, and NO production and iNOS inhibition can protect the tissue from damage in this infection.
ISSN:0304-4920
2666-0059