Synthesis and Antimicrobial Activities of N-(Heteroaryl-substituted)-p-toluenesulphonamides

A new class of N-(heteroaryl-substituted)-p-toluenesulphonamides has been synthesized exhibiting antibacterial and antifungal properties. The condensation reaction of p-toluenesulphonyl chloride 1 with appropriate substituted amino pyridines 2a–g in acetone furnished N-(heteroaryl-substituted)-p-tol...

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Published inOrganic chemistry International Vol. 2014; pp. 1 - 5
Main Authors Chinwe Francisca, Ozoh, Chris, Okoro Uchechukwu, Izuchukwu, Ugwu David
Format Journal Article
LanguageEnglish
Published Hindawi Publishing Corporation 01.12.2014
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Summary:A new class of N-(heteroaryl-substituted)-p-toluenesulphonamides has been synthesized exhibiting antibacterial and antifungal properties. The condensation reaction of p-toluenesulphonyl chloride 1 with appropriate substituted amino pyridines 2a–g in acetone furnished N-(heteroaryl-substituted)-p-toluenesulphonamides 3a–g. These derivatives were characterized by IR, 1H-, and 13C-NMR spectroscopy and were screened in vitro against gram-positive bacteria, gram-negative bacteria, and fungi organisms using agar-diffusion method. Results indicated improved biological activities over reference drugs such as Tetracycline (TCN) and Fluconazole (FLU).
Bibliography:ObjectType-Article-1
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ISSN:2090-200X
2090-2018
DOI:10.1155/2014/748257