Prenatal exposure of bupropion may enhance agitation, anxiety responses, and sensitivity to cocaine effects in adult mice

• Published in: Chinese journal of physiology Vol. 50; no. 1; p. 1
• Main Authors: Su, Shu-Wen, Cherng, Chian-Fang G, Lin, Yin Chiu, Yu, Lung
• Format: Journal Article
• Language: English
• Published: India 28.02.2007
• Subjects: Aging; Animals; Antidepressive Agents, Second-Generation - administration & dosage; Anxiety - psychology; Bupropion - administration & dosage; Cocaine - pharmacology; Dose-Response Relationship, Drug; Female; Mice; Motor Activity - drug effects; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Agitation - physiopathology; Reward
• ISSN: 0304-4920

Major depression and dysthymia afflict a proportion of gravid and breast-feeding women. These women are frequently recommended on antidepressants to relieve their symptoms even if the drug effects on fetal growth and postnatal development are not completely known. In a previous study, we reported that prenatal bupropion exposure seemed to enhance the hedonic value of cocaine in adult mice. This study was undertaken to examine the dose-related effects for prenatal bupropion exposure on the stress susceptibility, cocaine-associated reinforcing property, and cocaine-induced behavioral sensitization in adult mice. Our results showed that various doses (ranging 12.5-50 mg/kg) of prenatal bupropion administration at the third trimester of pregnancy did not affect body weight of the adult mice. Bupropion administration at 50 mg/kg enhanced both ambulatory and rearing responses in the open field test. Moreover, bupropion administration (at 25 and 50 mg/kg) significantly decreased the numbers in open arm entry in the elevated plus maze test. Furthermore, prenatal bupropion treatment appeared to facilitate the cocaine-induced place preference in a sex-dependent manner. Finally, prenatal bupropion exposure (at 25 and 50 mg/kg) accelerated and elevated the development of cocaine-induced sensitization in locomotor activity. While the antidepressant and smoking-curbing effects of bupropion have been addressed in literature, we suggest that prenatal bupropion exposure could run a risk of enhancing individual's agitation, stress susceptibility and cocaine stimulating propensity in adulthood.