Effect of Different Organized Media on Ion-Selective Electrode (ISE) Determination of Propranolol in Pharmaceutical Dosage Forms

• Published in: Yàowu shi͡p︡in fenxi Vol. 17; no. 2; pp. 85 - 92
• Main Authors: El-Sherbiny, Dina, ELEWADY, Ghada YEHIA, SHALAB, KAMAL, El-Ask alany, Abde lmonem
• Format: Journal Article
• Language: English
• Published: 台灣 衛生福利部食品藥物管理署 01.04.2009; Food and Drug Administration
• Subjects: Dosage forms; Ion selective electrode; MEDLINE; Organized media; Polyvinyl chloride; Propranolol; SCIE; Scopus; Selectivity coefficient; 劑型; 普潘奈; 有序介質; 聚乙稀; 選擇系數; 離子選擇電極; organized media; selectivity coefficient; dosage forms; polyvinyl chloride; ion selective electrode; propranolol
• ISSN: 1021-9498; 2224-6614

This study examined the effect of different organized media such as β-cyclodextrin and micelle surfactants, either anionic (sodium dodecyl sulphate), cationic (cetrimide) or non-ionic (tween-20 and tween-80), on the potentiometric properties of propranolol polyvinyl chloride selective electrode based on tetraphenyl borate (PRO-TPB) ion-exchanger as an electroactive material. It was found that the Nernstian slope for propranolol over the concentration range of 1 × 10-5 to 10-2 M was unaffected by non ionic surfactant, whereas cationic surfactant significantly decreased the Nernstian slope. However, anionic surfactant significantly increased the Nernstian slope. The electrode basic analytical parameters such as measurement range, slope characteristics, detection limit, response time, and selectivity coefficients in relation to some inorganic cations, sugars, amino acids and some β-blockers were investigated in presence or absence of organized media. Electrode was used for the potentiometric determination of propranolol in pharmaceutical preparations with and without organised compounds. The results were consistent with those obtained using a reference method.