Intoxication caused by interaction of chloramphenicol and phenytoin

A patient with a brain tumor and seizures who was receiving maintenance doses of phenytoin was given chloramphenicol on three occasions. Her neurological status was both complicated and obscured by the reoccurrence of phenytoin intoxication. Retrospective drug analysis showed a marked elevation of s...

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Bibliographic Details
Published inJAMA : the journal of the American Medical Association Vol. 237; no. 24; p. 2630
Main Authors Rose, J Q, Choi, H K, Schentag, J J, Kinkel, W R, Jusko, W J
Format Journal Article
LanguageEnglish
Published United States 13.06.1977
Subjects
Chloramphenicol - pharmacology
Chloramphenicol - therapeutic use
Drug Interactions
Female
Hemangioma, Cavernous - drug therapy
Humans
Middle Aged
Phenytoin - blood
Phenytoin - poisoning
Phenytoin - therapeutic use
Sella Turcica
Shock - drug therapy
Stimulation, Chemical
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Summary:A patient with a brain tumor and seizures who was receiving maintenance doses of phenytoin was given chloramphenicol on three occasions. Her neurological status was both complicated and obscured by the reoccurrence of phenytoin intoxication. Retrospective drug analysis showed a marked elevation of serum concentrations of phenytoin during each course of chloramphenicol.
ISSN:0098-7484
DOI:10.1001/jama.1977.03270510052024