Duboscic Acid: A Potent α-Glucosidase Inhibitor with an Unprecedented Triterpenoidal Carbon Skeleton from Duboscia macrocarpa

Duboscic acid (1), a triterpenoid with a unique carbon backbone, was isolated from Duboscia macrocarpa Bocq. It is the first member of a new class of triterpenoids, for which the name “dubosane” is proposed. Duboscic acid has a potent α-glucosidase inhibition, and its structure was unambiguously ded...

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Bibliographic Details
Published inOrganic letters Vol. 12; no. 24; pp. 5760 - 5763
Main Authors Wafo, Pascal, Kamdem, Ramsay S. T, Ali, Zulfiqar, Anjum, Shazia, Khan, Shamsun Nahar, Begum, Afshan, Krohn, Karsten, Abegaz, Berhanu M, Ngadjui, Bonaventure T, Choudhary, Muhammad Iqbal
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 17.12.2010
Amer Chemical Soc
Subjects
Althaea - chemistry
Chemistry
Chemistry, Organic
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Glycoside Hydrolase Inhibitors
Models, Molecular
Molecular Structure
Physical Sciences
Science & Technology
Triterpenes - chemistry
Triterpenes - pharmacology
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Summary:Duboscic acid (1), a triterpenoid with a unique carbon backbone, was isolated from Duboscia macrocarpa Bocq. It is the first member of a new class of triterpenoids, for which the name “dubosane” is proposed. Duboscic acid has a potent α-glucosidase inhibition, and its structure was unambiguously deduced by a single-crystal X-ray diffraction study.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol1026552