Cryptococcus neoformans as a cause of lytic bone lesions

Cryptococcosis is a disseminated infection of man and animals that involves many organs, especially the central nervous system. Isolated bone involvement may cause lytic bone lesions. Diagnosis may be made by pathologic sections and culture of specimens obtained through surgical biopsy. When Cryptoc...

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Bibliographic Details
Published inJAMA : the journal of the American Medical Association Vol. 231; no. 10; p. 1057
Main Authors Burch, K H, Fine, G, Quinn, E L, Eisses, J F
Format Journal Article
LanguageEnglish
Published United States 10.03.1975
Subjects
Adult
Antibodies, Fungal - analysis
Biopsy
Clavicle - diagnostic imaging
Clavicle - pathology
Cryptococcosis - complications
Cryptococcus - isolation & purification
Cryptococcus neoformans - isolation & purification
Drainage
Female
Humans
Humerus - diagnostic imaging
Humerus - microbiology
Humerus - pathology
Osteomyelitis - etiology
Osteomyelitis - immunology
Osteomyelitis - pathology
Osteomyelitis - surgery
Radiography
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Summary:Cryptococcosis is a disseminated infection of man and animals that involves many organs, especially the central nervous system. Isolated bone involvement may cause lytic bone lesions. Diagnosis may be made by pathologic sections and culture of specimens obtained through surgical biopsy. When Cryptococcus is recovered from bone, care must be taken to study other organ systems, especially the central nervous system. Isolated bone disease without meningitis is very uncommom. Intense medical therapy is necessary for treatment of meningitis; isolated osteomyelitis may respond to surgical drainage alone.
ISSN:0098-7484
DOI:10.1001/jama.1975.03240220037017