Renal thromboxane synthesis in excised kidney distal to renovascular lesions

• Published in: JAMA : the journal of the American Medical Association Vol. 251; no. 23; p. 3118
• Main Authors: Anderson, C B, Tannenbaum, J S, Sicard, G A, Etheredge, E E
• Format: Journal Article
• Language: English
• Published: United States 15.06.1984
• Subjects: Humans; Hypertension, Renovascular - metabolism; Hypertension, Renovascular - pathology; Hypertension, Renovascular - surgery; In Vitro Techniques; Ischemia - etiology; Ischemia - metabolism; Ischemia - pathology; Kidney - blood supply; Kidney - metabolism; Kidney - pathology; Male; Middle Aged; Nephrectomy; Prostaglandins - biosynthesis; Renal Artery - abnormalities; Thromboxane A2 - biosynthesis; Thromboxane B2 - biosynthesis; Thromboxanes - biosynthesis
• ISSN: 0098-7484
• DOI: 10.1001/jama.1984.03340470044024

Excision of a kidney with three distinct zones of perfusion was required in a patient with renovascular hypertension. One third of the kidney was normal, one third was ischemic from a stenotic artery, and one third was severely ischemic from a completely occluded artery. This provided a unique opportunity to study renal prostaglandin production in hypoperfused and control tissue by radioimmunoassays of incubated tissue slices. The thromboxane-prostacyclin synthesis ratio for the outer cortex increased from 2.2 in control tissue to 5.8 in moderately ischemic tissue and 11.3 in severely ischemic tissue; for the inner cortex, 2.1 to 6.3 and 8.8; and for the medulla, 0.4 to 1.2 and 3.0, respectively . Similar ratios were noted for thromboxane-prostaglandin E2. This correlates, for the first time in man, absolute and relative increases in renal thromboxane synthesis with renovascular hypertension.