Immunological impairment and susceptibility to infection after splenectomy

Asplenic patients or those who have undergone splenectomy are prone to overwhelming and often fatal sepsis, which is sometimes associated with disseminated intravascular coagulopathies. Although several pathogens are involved, the most common organism found in these subjects is the pneumococcus, and...

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Bibliographic Details
Published inJAMA : the journal of the American Medical Association Vol. 236; no. 12; p. 1376
Main Author Likhite, V V
Format Journal Article
LanguageEnglish
Published United States 20.09.1976
Subjects
Animals
Antibody Formation
Humans
Immunoglobulin G - biosynthesis
Immunoglobulin M - biosynthesis
Immunologic Deficiency Syndromes - etiology
Infection - immunology
Spleen - abnormalities
Spleen - immunology
Splenectomy - adverse effects
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Summary:Asplenic patients or those who have undergone splenectomy are prone to overwhelming and often fatal sepsis, which is sometimes associated with disseminated intravascular coagulopathies. Although several pathogens are involved, the most common organism found in these subjects is the pneumococcus, and the infections respond poorly to antibiotic therapy.
ISSN:0098-7484
DOI:10.1001/jama.1976.03270130038024