Identification and Evaluation of Antiepileptic Activity of C21 Steroidal Glycosides from the Roots of Cynanchum wilfordii

Nine new C21 steroidal glycosides, named cynawilfosides A–I (1–9), along with 12 known compounds were isolated from the roots of Cynanchum wilfordii. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The five major components, cynawilfoside A (1), cy...

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Published inJournal of natural products (Washington, D.C.) Vol. 79; no. 1; pp. 89 - 97
Main Authors Li, Jin-Long, Gao, Zhao-Bing, Zhao, Wei-Min
Format Journal Article
LanguageEnglish
Published United States American Chemical Society and American Society of Pharmacognosy 22.01.2016
Subjects
Animals
Anticonvulsants - chemistry
Anticonvulsants - isolation & purification
Anticonvulsants - pharmacology
Cynanchum - chemistry
Disease Models, Animal
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Mice
Molecular Structure
Plant Roots - chemistry
Pregnanes - chemistry
Pregnanes - isolation & purification
Pregnanes - pharmacology
Saponins
Seizures
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Summary:Nine new C21 steroidal glycosides, named cynawilfosides A–I (1–9), along with 12 known compounds were isolated from the roots of Cynanchum wilfordii. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The five major components, cynawilfoside A (1), cynauricoside A (11), wilfoside C1N (16), wilfoside K1N (17), and cyanoauriculoside G (18), exhibited significant protection activity in a maximal electroshock (MES)-induced mouse seizure model with ED50 values of 48.5, 95.3, 124.1, 72.3, and 88.1 mg/kg, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.5b00766