A Facile FeCl3/I2‑Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones

A facile and efficient route for the synthesis of tetrasubstituted imidazoles from amidines and chalcones via FeCl3/I2-catalyzed aerobic oxidative coupling has been developed. This new strategy is featured by high regioselectivity and yields, good functional group tolerance, and mild reaction condit...

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Published inOrganic letters Vol. 17; no. 15; pp. 3872 - 3875
Main Authors Zhu, Yuelu, Li, Cheng, Zhang, Jidong, She, Mengyao, Sun, Wei, Wan, Kerou, Wang, Yaqi, Yin, Bin, Liu, Ping, Li, Jianli
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 07.08.2015
Subjects
Amidines - chemistry
Catalysis
Chalcones - chemistry
Chlorides - chemistry
Ferric Compounds - chemistry
Imidazoles - chemical synthesis
Imidazoles - chemistry
Iodine - chemistry
Molecular Structure
Oxidative Coupling
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Summary:A facile and efficient route for the synthesis of tetrasubstituted imidazoles from amidines and chalcones via FeCl3/I2-catalyzed aerobic oxidative coupling has been developed. This new strategy is featured by high regioselectivity and yields, good functional group tolerance, and mild reaction conditions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b01854