Visible-Light Photoredox-Catalyzed Intermolecular α‑Aminomethyl/Carboxylative Dearomatization of Indoles with CO2 and α‑Aminoalkyl Radical Precursors

Disclosed here is a visible-light photoredox-catalyzed intermolecular sequential α-aminomethyl/carboxylative dearomatization of indoles with CO2 and α-aminoalkyl radical precursors, affording a series of functionalized indoline-3-carboxylic acids and lactams in good yields with high regioselectivity...

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Bibliographic Details
Published inOrganic letters Vol. 26; no. 2; pp. 467 - 472
Main Authors Gao, Wanxu, Yang, Qi, Yang, Han, Yao, Yang, Bai, Junxue, Sun, Jianwei, Sun, Song
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 19.01.2024
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ALCOHOLS
ASYMMETRIC DEAROMATIZATION
ALKENES
ACIDS
ALLYLATION
CARBOXYLATION
CARBON-DIOXIDE
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Summary:Disclosed here is a visible-light photoredox-catalyzed intermolecular sequential α-aminomethyl/carboxylative dearomatization of indoles with CO2 and α-aminoalkyl radical precursors, affording a series of functionalized indoline-3-carboxylic acids and lactams in good yields with high regioselectivity. This multicomponent reaction provides a green and facile method for the synthesis of diverse functionalized indolines by using CO2 as the carboxylic and carbonyl source.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c03755